Cities are at the frontline of response to multiple crises that the contemporary world faces, which, if managed well, could open up tremendous possible futures for the way we plan, manage, and govern cities. As a home for already more than half of the world’s population, centers of innovation, magnets of talent, and locus of economic productivity, cities are uniquely placed to reflect on the quality of life, address well-being, and prototype solutions to global problems, capturing advances in Artificial Intelligence for the benefit of all people. At the same time, cities are called to lead the response to the climate crisis through localizing global frames of reference towards urban resilience.